Recent advances and safety issues of transgenic plant-derived vaccines
Identifieur interne : 001A65 ( Main/Exploration ); précédent : 001A64; suivant : 001A66Recent advances and safety issues of transgenic plant-derived vaccines
Auteurs : Zheng-Jun Guan [République populaire de Chine] ; Bin Guo [République populaire de Chine] ; Yan-Lin Huo [République populaire de Chine] ; Zheng-Ping Guan [République populaire de Chine] ; Jia-Kun Dai [République populaire de Chine] ; Ya-Hui Wei [République populaire de Chine]Source :
- Applied Microbiology and Biotechnology [ 0175-7598 ] ; 2013-04-01.
Descripteurs français
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Plant, Safety, Transgenic, Vaccine.
Abstract
Abstract: Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines.
Url:
DOI: 10.1007/s00253-012-4566-2
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001090
- to stream Istex, to step Curation: 001090
- to stream Istex, to step Checkpoint: 000343
- to stream Main, to step Merge: 001A75
- to stream Main, to step Curation: 001A65
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent advances and safety issues of transgenic plant-derived vaccines</title><author><name sortKey="Guan, Zheng Jun" sort="Guan, Zheng Jun" uniqKey="Guan Z" first="Zheng-Jun" last="Guan">Zheng-Jun Guan</name></author><author><name sortKey="Guo, Bin" sort="Guo, Bin" uniqKey="Guo B" first="Bin" last="Guo">Bin Guo</name></author><author><name sortKey="Huo, Yan Lin" sort="Huo, Yan Lin" uniqKey="Huo Y" first="Yan-Lin" last="Huo">Yan-Lin Huo</name></author><author><name sortKey="Guan, Zheng Ping" sort="Guan, Zheng Ping" uniqKey="Guan Z" first="Zheng-Ping" last="Guan">Zheng-Ping Guan</name></author><author><name sortKey="Dai, Jia Kun" sort="Dai, Jia Kun" uniqKey="Dai J" first="Jia-Kun" last="Dai">Jia-Kun Dai</name></author><author><name sortKey="Wei, Ya Hui" sort="Wei, Ya Hui" uniqKey="Wei Y" first="Ya-Hui" last="Wei">Ya-Hui Wei</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BA582096BB00778B7D3622CF31C58F169735DCEA</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1007/s00253-012-4566-2</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-FLVJ7SDQ-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001090</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001090</idno><idno type="wicri:Area/Istex/Curation">001090</idno><idno type="wicri:Area/Istex/Checkpoint">000343</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000343</idno><idno type="wicri:doubleKey">0175-7598:2013:Guan Z:recent:advances:and</idno><idno type="wicri:Area/Main/Merge">001A75</idno><idno type="wicri:Area/Main/Curation">001A65</idno><idno type="wicri:Area/Main/Exploration">001A65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Recent advances and safety issues of transgenic plant-derived vaccines</title><author><name sortKey="Guan, Zheng Jun" sort="Guan, Zheng Jun" uniqKey="Guan Z" first="Zheng-Jun" last="Guan">Zheng-Jun Guan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, 710069, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Life Sciences, Yuncheng University, 044000, Yuncheng, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, 100093, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Guo, Bin" sort="Guo, Bin" uniqKey="Guo B" first="Bin" last="Guo">Bin Guo</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, 710069, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author><author><name sortKey="Huo, Yan Lin" sort="Huo, Yan Lin" uniqKey="Huo Y" first="Yan-Lin" last="Huo">Yan-Lin Huo</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Biological and Chemical Exiperiment, Yuncheng University, 044000, Yuncheng, Shanxi</wicri:regionArea><wicri:noRegion>Shanxi</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Zheng Ping" sort="Guan, Zheng Ping" uniqKey="Guan Z" first="Zheng-Ping" last="Guan">Zheng-Ping Guan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Animal Science and Technology, Nanjing Agriculture University, 210095, Nanjing, Jiangshu</wicri:regionArea><wicri:noRegion>Jiangshu</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Jia Kun" sort="Dai, Jia Kun" uniqKey="Dai J" first="Jia-Kun" last="Dai">Jia-Kun Dai</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Enzyme Engineering Institute of Shaanxi, Academy of Sciences, 710600, Xi’an, Shaanxi</wicri:regionArea><wicri:noRegion>Shaanxi</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Ya Hui" sort="Wei, Ya Hui" uniqKey="Wei Y" first="Ya-Hui" last="Wei">Ya-Hui Wei</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, 710069, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Applied Microbiology and Biotechnology</title><title level="j" type="abbrev">Appl Microbiol Biotechnol</title><idno type="ISSN">0175-7598</idno><idno type="eISSN">1432-0614</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2013-04-01">2013-04-01</date><biblScope unit="volume">97</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="2817">2817</biblScope><biblScope unit="page" to="2840">2840</biblScope></imprint><idno type="ISSN">0175-7598</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0175-7598</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Plant</term><term>Safety</term><term>Transgenic</term><term>Vaccine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Guan, Zheng Jun" sort="Guan, Zheng Jun" uniqKey="Guan Z" first="Zheng-Jun" last="Guan">Zheng-Jun Guan</name></noRegion><name sortKey="Dai, Jia Kun" sort="Dai, Jia Kun" uniqKey="Dai J" first="Jia-Kun" last="Dai">Jia-Kun Dai</name><name sortKey="Guan, Zheng Jun" sort="Guan, Zheng Jun" uniqKey="Guan Z" first="Zheng-Jun" last="Guan">Zheng-Jun Guan</name><name sortKey="Guan, Zheng Jun" sort="Guan, Zheng Jun" uniqKey="Guan Z" first="Zheng-Jun" last="Guan">Zheng-Jun Guan</name><name sortKey="Guan, Zheng Ping" sort="Guan, Zheng Ping" uniqKey="Guan Z" first="Zheng-Ping" last="Guan">Zheng-Ping Guan</name><name sortKey="Guo, Bin" sort="Guo, Bin" uniqKey="Guo B" first="Bin" last="Guo">Bin Guo</name><name sortKey="Guo, Bin" sort="Guo, Bin" uniqKey="Guo B" first="Bin" last="Guo">Bin Guo</name><name sortKey="Huo, Yan Lin" sort="Huo, Yan Lin" uniqKey="Huo Y" first="Yan-Lin" last="Huo">Yan-Lin Huo</name><name sortKey="Wei, Ya Hui" sort="Wei, Ya Hui" uniqKey="Wei Y" first="Ya-Hui" last="Wei">Ya-Hui Wei</name><name sortKey="Wei, Ya Hui" sort="Wei, Ya Hui" uniqKey="Wei Y" first="Ya-Hui" last="Wei">Ya-Hui Wei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:BA582096BB00778B7D3622CF31C58F169735DCEA
|texte= Recent advances and safety issues of transgenic plant-derived vaccines
}}
| This area was generated with Dilib version V0.6.33. |  |